Alternative Names:
ATP-binding cassette sub-family G member 2; Urate exporter; CD338; ABCP; BCRP; BCRP1; MXR1;
Application:
WB
Reactivity:
Human
Dilution:
WB 1:500~1:2000
| Western blot analysis of ABCG2 expression in 293T cell lysate. |
|
Purification:
Affinity-chromatography
Specificity:
ABCG2 Antibody detects endogenous levels of total ABCG2
Immunogen:
A synthesized peptide derived from human ABCG2
Description:
ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
