Alternative Names:

ATF2, Activating 2, CREB2, CREBP1, Cyclic-AMP-dependent ATF-2, HB16, MXBP protein, cAMP response element binding protein CRE- BP1

Application:

WB  IHC IP

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:2000    IHC 1:50-1:200  IP

Western blot analysis of ATF2 phosphorylation expression in TNF-α treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

Phospho-ATF2 (Ser62 or 44) Antibody detects endogenous levels of ATF2 only when phosphorylated at Serine 62 or 44

Immunogen:

A synthesized peptide derived from human ATF2 around the phosphorylation site of Serine 62 or 44

Description:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro;

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.